CHIEN LAB Biosystem IC devices

Publications

2023

Dual-Aptamer Drift Canceling Techniques to Improve Long-Term Stability of Real-Time Structure-Switching Aptasensors
Ya-Chen Tsai, Wei-Yang Weng, Yu-Tung Yeh, Jun-Chau Chien
ACS Sensors   ·   06 Sep 2023   ·   doi:10.1021/acssensors.3c00509
A Thru-Reflect-Series-Resistance (TRS) Calibration for Cryogenic Device Characterization in 40-nm CMOS Technology
Yi-Ting Chen, Ian Huang, Min-Jui Lin, Shu-Yan Chuang, Hua Ling Ho, ..., Sih-Ying Chen, Liang-Hung Lu, Shih-Yuan Chen, Jiun-Yun Li, Jun-Chau Chien
2023 IEEE/MTT-S International Microwave Symposium - IMS 2023   ·   11 Jun 2023   ·   doi:10.1109/IMS37964.2023.10188078
A CMOS/Microfluidics Point-of-Care SoC employing Square-Wave Voltcoulometry for Biosensing with Aptamers and CRISPR-Cas12a Enzymes
Yan-Ting Hsiao, Shu-Yan Chuang, Hung-Yu Hou, Yun-Chun Su, Hsiu-Cheng Yeh, ..., Pin-Yu Lin, Sih-Ying Chen, Yen-Ju Lin, Mei-Wei Lin, Jun-Chau Chien
2023 IEEE Symposium on VLSI Technology and Circuits (VLSI Technology and Circuits)   ·   11 Jun 2023   ·   doi:10.23919/VLSITechnologyandCir57934.2023.10185383
A 13-GHz “3-D” Near-Field Imager Employing Programmable Fringing Fields for Cancer Imaging
Zong-Jun Cheng, Shu-Yan Chuang, Wei-Yang Weng, Guan-Yu Huang, Yan-Huei Li, ..., Yu-Cheng Lin, Yun-Jui Chang, Hung-Yu Hou, Yi-Ting Chen, Jun-Chau Chien
IEEE Microwave and Wireless Technology Letters   ·   01 Jun 2023   ·   doi:10.1109/LMWT.2023.3265584
CMOS-Embedded 3D Micro/Nanofluidics Employing Top-Down Beol Single-Step Wet-Etching Technique
Wei-Yang Weng, Hung-Yu Hou, Yueh-Jung Chao, Shwu-Jen Liaw, Jun-Chau Chien
2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS)   ·   15 Jan 2023   ·   doi:10.1109/MEMS49605.2023.10052329

2022

Wireless Monitoring of Small Molecules on a Freely-Moving Animal using Electrochemical Aptamer Biosensors
Jun-Chau Chien, Sam W. Baker, Katherine Gates, Ji-Won Seo, Amin Arbabian, H. Tom Soh
2022 IEEE Biomedical Circuits and Systems Conference (BioCAS)   ·   13 Oct 2022   ·   doi:10.1109/BioCAS54905.2022.9948586
A Single-Element CMOS-LRRM VNA Electronic Calibration Technique
Jun-Chau Chien, Ali M. Niknejad
2022 99th ARFTG Microwave Measurement Conference (ARFTG)   ·   24 Jun 2022   ·   doi:10.1109/ARFTG54656.2022.9896578
Millimeter-wave VNA Calibration using a CMOS Transmission Line with Distributed Switches
Jun-Chau Chien
2022 IEEE Radio Frequency Integrated Circuits Symposium (RFIC)   ·   19 Jun 2022   ·   doi:10.1109/RFIC54546.2022.9863095
A Scalable Standing-Wave-Oscillator-based Imager with Near-Field-Modulated Pixels Achieving 64% Filling Factor for RF Intraoperative Imaging
Jun-Chau Chien, Zong-Jun Cheng, Shu-Yan Chuang, Hsiu-Cheng Yeh, Guan-Yu Huang, Hung-Yu Hou, Yi-Ting Chen, Wei-Yang Weng, Chi-Yang Tseng, Liang-In Lin
2022 IEEE Symposium on VLSI Technology and Circuits (VLSI Technology and Circuits)   ·   12 Jun 2022   ·   doi:10.1109/VLSITechnologyandCir46769.2022.9830290
Combinatorial Polyacrylamide Hydrogels for Preventing Biofouling on Implantable Biosensors
Doreen Chan, Jun‐Chau Chien, Eneko Axpe, Louis Blankemeier, Samuel W. Baker, ..., Caitlin L. Maikawa, Abigail K. Grosskopf, Joseph L. Mann, H. Tom Soh, Eric A. Appel
Advanced Materials   ·   12 May 2022   ·   doi:10.1002/adma.202109764

2021

Gigahertz frequency fringing near-field cardiovascular sensor
Jun-Chau Chien, Stanley Yuanshih Chen
[no publisher info]   ·   10 Aug 2021   ·   google.patent:US11083388B2

2020

Design and Analysis of a Sample-and-Hold CMOS Electrochemical Sensor for Aptamer-Based Therapeutic Drug Monitoring
Jun-Chau Chien, Sam W. Baker, H. Tom Soh, Amin Arbabian
IEEE Journal of Solid-State Circuits   ·   01 Nov 2020   ·   doi:10.1109/JSSC.2020.3020789
A 1.8-GHz Near-Field Dielectric Plethysmography Heart-Rate Sensor With Time-Based Edge Sampling
Jun-Chau Chien
IEEE Journal of Solid-State Circuits   ·   01 Mar 2020   ·   doi:10.1109/JSSC.2019.2951691
26.4 A Cell-Capacitance-Insensitive CMOS Sample-and-Hold Chronoamperometric Sensor for Real-Time Measurement of Small Molecule Drugs in Whole Blood
Jun-Chau Chien, Hyongsok Tom Soh, Amin Arbabian
2020 IEEE International Solid- State Circuits Conference - (ISSCC)   ·   01 Feb 2020   ·   doi:10.1109/ISSCC19947.2020.9063036

2019

An Aptamer-based Electrochemical-Sensing Implant for Continuous Therapeutic- Drug Monitoring in vivo
Jun-Chau Chien, Peter L. Mage, H. Tom Soh, Amin Arbabian
2019 Symposium on VLSI Circuits   ·   01 Jun 2019   ·   doi:10.23919/VLSIC.2019.8777991
A 20.1-μW 1.8 -GHz Near-Field Dielectric Plethysmography (NF-DPG) Heart-Rate Sensor with Time-based Edge Sampling
Jun-Chau Chien
2019 IEEE Custom Integrated Circuits Conference (CICC)   ·   01 Apr 2019   ·   doi:10.1109/CICC.2019.8780179

2018

A Single- Element VNA Electronic Calibration in CMOS
Jun-Chau Chien, Amin Arbabian, Ali M. Niknejad
2018 IEEE/MTT-S International Microwave Symposium - IMS   ·   01 Jun 2018   ·   doi:10.1109/MWSYM.2018.8439332
A Wireless Implantable Ultrasound Array Receiver for Thermoacoustic Imaging
Ahmed Sawaby, Max L. Wang, Ernest So, Jun-Chau Chien, Hao Nan, Butrus T. Khuri-Yakub, Amin Arbabian
2018 IEEE Symposium on VLSI Circuits   ·   01 Jun 2018   ·   doi:10.1109/VLSIC.2018.8502293
A high-throughput flow cytometry-on-a-CMOS platform for single-cell dielectric spectroscopy at microwave frequencies
Jun-Chau Chien, Ali Ameri, Erh-Chia Yeh, Alison N. Killilea, Mekhail Anwar, Ali M. Niknejad
Lab on a Chip   ·   01 Jan 2018   ·   doi:10.1039/C8LC00299A
A dual-element VNA electronic calibration in CMOS
Jun-Chau Chien, Amin Arbabian, Ali M. Niknejad
2018 IEEE 18th Topical Meeting on Silicon Monolithic Integrated Circuits in RF Systems (SiRF)   ·   01 Jan 2018   ·   doi:10.1109/SIRF.2018.8304233

2017

A CMOS single-cell deformability analysis using 3D hydrodynamic stretching in a GHz dielectric flow cytometry
Jun-Chau Chien, Mekhail Anwar, Ali M. Niknejad
2017 IEEE MTT-S International Microwave Symposium (IMS)   ·   01 Jun 2017   ·   doi:10.1109/MWSYM.2017.8058717
CMOS Microflow Cytometer for Magnetic Label Detection and Classification
Pramod Murali, Ali M. Niknejad, Bernhard E. Boser
IEEE Journal of Solid-State Circuits   ·   01 Feb 2017   ·   doi:10.1109/JSSC.2016.2621036

2016

Design and Analysis of Chopper Stabilized Injection-Locked Oscillator Sensors Employing Near-Field Modulation
Jun-Chau Chien, Ali M. Niknejad
IEEE Journal of Solid-State Circuits   ·   01 Aug 2016   ·   doi:10.1109/JSSC.2016.2573300
Oscillator-Based Reactance Sensors With Injection Locking for High-Throughput Flow Cytometry Using Microwave Dielectric Spectroscopy
Jun-Chau Chien, Ali M. Niknejad
IEEE Journal of Solid-State Circuits   ·   01 Feb 2016   ·   doi:10.1109/JSSC.2015.2500362

2015

Sensor-on-CMOS dielectric characterization using temperature modulation
Jun-Chau Chien, Ali M. Niknejad
2015 86th ARFTG Microwave Measurement Conference   ·   01 Dec 2015   ·   doi:10.1109/ARFTG.2015.7381458
A near-field modulation chopping stabilized injection-locked oscillator sensor for protein conformation detection at microwave frequency
Jun-Chau Chien, Erh-Chia Yeh, Luke P. Lee, Mekhail Anwar, Ali M. Niknejad
2015 Symposium on VLSI Circuits (VLSI Circuits)   ·   01 Jun 2015   ·   doi:10.1109/VLSIC.2015.7231312
A single-element CMOS-based electronic de-embedding technique with TRL level of accuracy
Jun-Chau Chien, Ali M. Niknejad
2015 IEEE MTT-S International Microwave Symposium   ·   01 May 2015   ·   doi:10.1109/MWSYM.2015.7166871
Impedance renormalization in CMOS-based single-element electronic de-embedding
Jun-Chau Chienand, Ali M. Niknejad
2015 85th Microwave Measurement Conference (ARFTG)   ·   01 May 2015   ·   doi:10.1109/ARFTG.2015.7162910
A microwave reconfigurable dielectric-based glucose sensor with 20 mg/dL sensitivity at sub-nL sensing volume in CMOS
Jun-Chau Chien, Erh-Chia Yeh, Luke P. Lee, Mekhail Anwar, Ali M. Niknejad
2015 IEEE MTT-S International Microwave Symposium   ·   01 May 2015   ·   doi:10.1109/MWSYM.2015.7167141
Design and Analysis on Bidirectionally and Passively Coupled QVCO With Nonlinear Coupler
Nai-Chung Kuo, Jun-Chau Chien, Ali M. Niknejad
IEEE Transactions on Microwave Theory and Techniques   ·   01 Apr 2015   ·   doi:10.1109/TMTT.2015.2407356

2014

A W-Band Low-Noise PLL With a Fundamental VCO in SiGe for Millimeter-Wave Applications
Shinwon Kang, Jun-Chau Chien, Ali M. Niknejad
IEEE Transactions on Microwave Theory and Techniques   ·   01 Oct 2014   ·   doi:10.1109/TMTT.2014.2345342
Injection-controlled-locked phase-locked loop
Jun-Chau Chien, Wayne Fang, Parag Upadhyaya, Jafar Savoj, Kun-Yung Chang
[no publisher info]   ·   23 Sep 2014   ·   google.patent:US8841948B1
A 26-GHz low-phase-error in-phase-coupled QVCO using modified bi-directional diodes
Jun-Chau Chien, Nai-Chung Kuo, Ali M. Niknejad
2014 IEEE Radio Frequency Integrated Circuits Symposium   ·   01 Jun 2014   ·   doi:10.1109/RFIC.2014.6851712
A 6.5/17.5-GHz dual-channel interferometer-based capacitive Sensor in 65-nm CMOS for high-speed flow cytometry
Jun-Chau Chien, Mekhail Anwar, Erh-Chia Yeh, Luke P. Lee, Ali M. Niknejad
2014 IEEE MTT-S International Microwave Symposium (IMS2014)   ·   01 Jun 2014   ·   doi:10.1109/MWSYM.2014.6848507
A 6.5/11/17.5/30-GHz high throughput interferometer-based reactance sensors using injection-locked oscillators and ping-pong nested chopping
Jun-Chau Chien, Mekhail Anwar, Erh-Chia Yeh, Luke P. Lee, Ali M. Niknejad
2014 Symposium on VLSI Circuits Digest of Technical Papers   ·   01 Jun 2014   ·   doi:10.1109/VLSIC.2014.6858408
2.8 A pulse-position-modulation phase-noise-reduction technique for a 2-to-16GHz injection-locked ring oscillator in 20nm CMOS
Jun-Chau Chien, Parag Upadhyaya, Howard Jung, Stanley Chen, Wayne Fang, Ali M. Niknejad, Jafar Savoj, Ken Chang
2014 IEEE International Solid-State Circuits Conference Digest of Technical Papers (ISSCC)   ·   01 Feb 2014   ·   doi:10.1109/ISSCC.2014.6757334

2013

A 1–50 GHz dielectric spectroscopy biosensor with integrated receiver front-end in 65nm CMOS
Jun-Chau Chien, Mekhail Anwar, Erh-Chia Yeh, Luke P. Lee, Ali M. Niknejad
2013 IEEE MTT-S International Microwave Symposium Digest (MTT)   ·   01 Jun 2013   ·   doi:10.1109/MWSYM.2013.6697466
A 94 GHz mm-Wave-to-Baseband Pulsed-Radar Transceiver with Applications in Imaging and Gesture Recognition
Amin Arbabian, Steven Callender, Shinwon Kang, Mustafa Rangwala, Ali M. Niknejad
IEEE Journal of Solid-State Circuits   ·   01 Apr 2013   ·   doi:10.1109/JSSC.2013.2239004

2012

Self-Aligned, Extremely High Frequency III–V Metal-Oxide-Semiconductor Field-Effect Transistors on Rigid and Flexible Substrates
Chuan Wang, Jun-Chau Chien, Hui Fang, Kuniharu Takei, Junghyo Nah, E. Plis, Sanjay Krishna, Ali M. Niknejad, Ali Javey
Nano Letters   ·   03 Jul 2012   ·   doi:10.1021/nl301699k
Extremely Bendable, High-Performance Integrated Circuits Using Semiconducting Carbon Nanotube Networks for Digital, Analog, and Radio-Frequency Applications
Chuan Wang, Jun-Chau Chien, Kuniharu Takei, Toshitake Takahashi, Junghyo Nah, Ali M. Niknejad, Ali Javey
Nano Letters   ·   09 Feb 2012   ·   doi:10.1021/nl2043375

2011

A 100GHz phase-locked loop in 0.13µm SiGe BiCMOS process
Shinwon Kang, Jun-Chau Chien, Ali M. Niknejad
2011 IEEE Radio Frequency Integrated Circuits Symposium   ·   01 Jun 2011   ·   doi:10.1109/RFIC.2011.5940606
A 90GHz pulsed-transmitter with near-field/far-field energy cancellation using a dual-loop antenna
Amin Arbabian, Shinwon Kang, Steven Callender, Bagher Afshar, Jun-Chau Chien, Ali Niknejad
2011 IEEE Radio Frequency Integrated Circuits Symposium   ·   01 Jun 2011   ·   doi:10.1109/RFIC.2011.5940672

2010

A 90 GHz Hybrid Switching Pulsed-Transmitter for Medical Imaging
Amin Arbabian, Steven Callender, Shinwon Kang, Bagher Afshar, Jun-Chau Chien, Ali M. Niknejad
IEEE Journal of Solid-State Circuits   ·   01 Dec 2010   ·   doi:10.1109/JSSC.2010.2077150
A 90GHz-carrier 30GHz-bandwidth hybrid switching transmitter with integrated antenna
Amin Arbabian, Bagher Afshar, Jun-Chau Chien, Shinwon Kang, Steven Callender, Ehsan Adabi, Stefano Dal Toso, Romain Pilard, Daniel Gloria, Ali Niknejad
2010 IEEE International Solid-State Circuits Conference - (ISSCC)   ·   01 Feb 2010   ·   doi:10.1109/ISSCC.2010.5433852

2007

40-Gb/s High-Gain Distributed Amplifiers With Cascaded Gain Stages in 0.18-$\mu{\hbox {m}}$ CMOS
Jun-Chau Chien, Liang-Hung Lu
IEEE Journal of Solid-State Circuits   ·   01 Dec 2007   ·   doi:10.1109/JSSC.2007.908688
A 32-GHz Rotary Traveling-Wave Voltage Controlled Oscillator in 0.18-$\mu{\hbox{m}}$ CMOS
Jun-Chau Chien, Liang-Hung Lu
IEEE Microwave and Wireless Components Letters   ·   01 Oct 2007   ·   doi:10.1109/LMWC.2007.905634
Analysis and Design of Wideband Injection-Locked Ring Oscillators With Multiple-Input Injection
Jun-Chau Chien, Liang-Hung Lu
IEEE Journal of Solid-State Circuits   ·   01 Sep 2007   ·   doi:10.1109/JSSC.2007.903058
Design of Wide-Tuning-Range Millimeter-Wave CMOS VCO With a Standing-Wave Architecture
Jun-Chau Chien, Liang-Hung Lu
IEEE Journal of Solid-State Circuits   ·   01 Sep 2007   ·   doi:10.1109/JSSC.2007.903050
A 20-Gb/s 1 : 2 Demultiplexer With Capacitive-Splitting Current-Mode-Logic Latches
Jun-Chau Chien, Liang-Hung Lu
IEEE Transactions on Microwave Theory and Techniques   ·   01 Aug 2007   ·   doi:10.1109/TMTT.2007.902071
A 10-Gb/s Inductorless CMOS Limiting Amplifier With Third-Order Interleaving Active Feedback
Huei-Yan Huang, Jun-Chau Chien, Liang-Hung Lu
IEEE Journal of Solid-State Circuits   ·   01 May 2007   ·   doi:10.1109/JSSC.2007.894819
40GHz Wide-Locking-Range Regenerative Frequency Divider and Low-Phase-Noise Balanced VCO in 0.18μm CMOS
Jun-Chau Chien, Liang-Hung Lu
2007 IEEE International Solid-State Circuits Conference. Digest of Technical Papers   ·   01 Feb 2007   ·   doi:10.1109/ISSCC.2007.373535

2006

A harmonic injection-locked frequency divider in 0.18-μm SiGe BiCMOS
Jun-Chau Chien, Chin-Shen Lin, Liang-Hung Lu, Huei Wang, J. Yeh, Chwan-Ying Lee, J. Chern
IEEE Microwave and Wireless Components Letters   ·   01 Oct 2006   ·   doi:10.1109/LMWC.2006.882383

2005

Ultra-Low-Voltage CMOS Static Frequency Divider
Jun-chau Chien, Liang-hung Lu
2005 IEEE Asian Solid-State Circuits Conference   ·   01 Nov 2005   ·   doi:10.1109/ASSCC.2005.251702
A wide-band CMOS injection-locked ring oscillator
Liang-Hung Lu, Jun-Chau Chien
IEEE Microwave and Wireless Components Letters   ·   01 Oct 2005   ·   doi:10.1109/LMWC.2005.856848

45.6-GHz matrix distributed amplifier in 0.18-μm CMOS
Tai-Yuan Chen, Jun-Chau Chien, Liang-Hung Lu
Proceedings of the IEEE 2005 Custom Integrated Circuits Conference, 2005.   ·   [no date info]   ·   doi:10.1109/CICC.2005.1568622
A 9.5-dB 50-GHz Matrix Distributed Amplifier in 0.18-μm CMOS
J.-C. Chien, T.-Y. Chen, L.-H. Lu
2006 Symposium on VLSI Circuits, 2006. Digest of Technical Papers.   ·   [no date info]   ·   doi:10.1109/VLSIC.2006.1705352
A 40-GHz Wide-Tuning-Range VCO in 0.18-~m CMOS
J.-C. Chien, L.-H. Lu
2006 Symposium on VLSI Circuits, 2006. Digest of Technical Papers.   ·   [no date info]   ·   doi:10.1109/VLSIC.2006.1705368